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Risperdal General Information

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Risperdal (generic name: risperidone; brand names include: Risdone) is a compound, which belongs to a new class of antipsychotic agents. Risperdal is generally well-tolerated.

Risperdal is indicated for the treatment of schizophrenia and other psychotic disorders. These include first episode psychoses, acute schizophrenic exacerbations, chronic schizophrenia and other psychotic conditions, in which positive symptoms (such as hallucinations, delusions, thought disturbances, hostility, suspiciousness), and/or negative symptoms (such as blunted effect, emotional and social withdrawal, poverty of speech) are prominent.

Risperdal is also indicated for the treatment and long term control of mania in bipolar disorder. These episodes are characterised by symptoms such as elevated, expansive or irritable mood, inflated self esteem, decreased need for sleep, pressured speech, racing thoughts, distractability, or poor judgement, including disruptive or aggressive behaviours.

Risperdal also alleviates affective symptoms (such as depression, guilt-feelings, anxiety) associated with schizophrenia.

Risperdal is also indicated for the treatment of behavioural and psychological symptoms of dementia such as aggressiveness (verbal outburst, physical violence), activity disturbance (agitation, wandering) or psychotic symptoms.

Risperdal is also indicated for the treatment of conduct and other disruptive behaviours such as aggression, impulsiveness and self-injury in children (over 5 years old), adolescents and adults who are intellectually disabled.

Risperdal is indicated for the treatment of autism in children and adolescents.

Risperdal also appears effective in maintaining the clinical improvement during continuation therapy.

Risperdal helps to correct a chemical imbalance in the brain associated with these conditions.

Risperdal is not addictive.


Risperdal (risperidone) is an antipsychotic medicine that works by changing the effects of chemicals in the brain. Risperdal is used to treat schizophrenia in adults and children who are at least 13 years old. Risperdal is also used to treat symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old. Does Risperdal cause any undesirable side effects? Risperdal is also used to treat symptoms of irritability in autistic children who are 5 to 16 years old. What is Risperdal? Dosage Info, Effects, Uses, Interactions.

Important Information

While you are taking this medicine, you may be more sensitive to extreme temperatures such as very hot or cold conditions. Avoid excessive cooling, overheating or dehydration. Drink plenty of fluids, especially in hot weather and exercise. When you take this medicine, it becomes dangerous to overheat and dehydrate. Risperidone can affect your thinking or reactions. Be careful if you are driving or doing anything that requires you to be on the lookout. Drinking alcohol can exacerbate certain side effects of risperidone. Stop using Risperdal and call your doctor immediately if you have fever, muscle stiffness, confusion, sweating, rapid or uneven heartbeat, restless facial or neck muscle movements, tremor (uncontrollable tremor), swallowing problems, feeling frivolous or fainting.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric.Appropriate studies have not been performed on the relationship of age to the effects of risperidone in children younger than 13 years of age with schizophrenia, in children younger than 10 years of age with bipolar disorder, or in children younger than 5 years of age with autistic disorder. Safety and efficacy have not been established.

Geriatric. Although appropriate studies on the relationship of age to the effects of risperidone have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of risperidone in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving risperidone.

Breastfeeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Chemical Classifications

Benzisoxazole

Risperdal side effects

Get emergency medical help if you have signs of an allergic reaction to Risperdal: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
  • breast swelling or tenderness (in men or women), nipple discharge, impotence, lack of interest in sex, missed menstrual periods;
  • severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
  • low white blood cells - sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
  • low levels of platelets in your blood - easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; or
  • penis erection that is painful or lasts 4 hours or longer.

Common Risperdal side effects may include:

  • headache;
  • dizziness, drowsiness, feeling tired;
  • tremors, twitching or uncontrollable muscle movements;
  • agitation, anxiety, restless feeling;
  • depressed mood;
  • dry mouth, upset stomach, diarrhea, constipation;
  • weight gain; or
  • cold symptoms such as stuffy nose, sneezing, sore throat.

Dosage

Irritability Associated with Autistic Disorder

The dosage of Risperdal should be individualized according to the response and tolerability of the patient. The total daily dose of Risperdal can be administered once daily, or half the total daily dose can be administered twice daily. For patients with body weight less than 20 kg, initiate dosing at 0.25 mg per day. For patients with body weight greater than or equal to 20 kg, initiate dosing at 0.5 mg per day. After a minimum of four days, the dose may be increased to the recommended dose of 0.5 mg per day for patients less than 20 kg and 1.0 mg per day for patients greater than or equal to 20 kg. Maintain this dose for a minimum of 14 days. In patients not achieving sufficient clinical response, the dose may be increased at intervals of 2 weeks or greater, in increments of 0.25 mg per day for patients less than 20 kg, or increments of 0.5 mg per day for patients greater than or equal to 20 kg. The effective dose range is 0.5 mg to 3 mg per day. No dosing data are available for children who weigh less than 15 kg. Once sufficient clinical response has been achieved and maintained, consider gradually lowering the dose to achieve the optimal balance of efficacy and safety. The physician who elects to use Risperdal for extended periods should periodically re-evaluate the long-term risks and benefits of the drug for the individual patient. Patients experiencing persistent somnolence may benefit from a once-daily dose administered at bedtime or administering half the daily dose twice daily, or a reduction of the dose.

Schizophrenia

Usual Adults Initial Dose

Risperdal can be administered once or twice daily. Initial dosing is 2 mg per day. May increase the dose at intervals of 24 hours or greater, in increments of 1 to 2 mg per day, as tolerated, to a recommended dose of 4 to 8 mg per day. In some patients, slower titration may be appropriate. Efficacy has been demonstrated in a range of 4 mg to 16 mg per day. However, doses above 6 mg per day for twice daily dosing were not demonstrated to be more efficacious than lower doses, were associated with more extrapyramidal symptoms and other adverse effects, and are generally not recommended. In a single study supporting once-daily dosing, the efficacy results were generally stronger for 8 mg than for 4 mg. The safety of doses above 16 mg per day has not been evaluated in clinical trials.

Bipolar Mania

Adults. The initial dose range is 2 mg to 3 mg per day. The dose may be adjusted at intervals of 24 hours or greater, in increments of 1 mg per day. The effective dose range is 1 mg to 6 mg per day, as studied in the short-term, placebo-controlled trials. In these trials, short-term (3 week) anti-manic efficacy was demonstrated in a flexible dosage range of 1 mg to 6 mg per day. Risperdal doses higher than 6 mg per day were not studied.

Pediatrics. The initial dose is 0.5 mg once daily, administered as a single-daily dose in the morning or evening. The dose may be adjusted at intervals of 24 hours or greater, in increments of 0.5 mg or 1 mg per day, as tolerated, to the recommended target dose of 1 mg to 2.5 mg per day. Although efficacy has been demonstrated in studies of pediatric patients with bipolar mania at doses between 0.5 mg and 6 mg per day, no additional benefit was observed above 2.5 mg per day, and higher doses were associated with more adverse events. Doses higher than 6 mg per day have not been studied.

Risperdal Recommendations

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Risperdal exactly as directed.

Take Risperdal by mouth with or without food. It is usually taken once or twice a day with or without food. Take Risperdal at around the same time(s) every day. Risperdal tablets should be swallowed with water or other liquid. Risperdal oral solution should be mixed with a non-alcoholic drink. Mineral water, orange juice, coffee and milk are suitable. Do not use tea.

Take Risperdal on a regular schedule to get the most benefit from it. Taking Risperdal at the same time each day will help you remember to take it.

It may take several weeks or longer before you feel the full benefit of Risperdal. Continue to take Risperdal even if you feel well. Do not stop taking Risperdal without talking to your doctor.

Avoid excessive eating.

If you forget to take Risperdal, take the missed dose as soon as you remember instead of your next dose. Then go back to taking it as you would normally. Do not take a double dose to make up for the one you missed. If you forget to take Risperdal for 5 days or more, tell your doctor before starting your medicine again.

Keep Risperdal tablets at room temperature. The oral solution should not be refrigerated.


Risperdal Precautions

Before you start to use it, tell your doctor if you are allergic to Risperdal or other medicines; also if you have: heart or blood vessel diseases, including low blood pressure; kidney or liver problems; diabetes, or dehydration; Parkinson's disease; dementia or Lewy body dementia; epilepsy; breast cancer; disease of the pituitary gland; Tardive dyskinesia or Neuroleptic Malignant Syndrome; if you are pregnant or are planning to become pregnant, or you are breast-feeding.


Risperdal Ingredients

Active ingredient: risperidone.

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