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Meldonium General Information

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Meldonium (mildronate) is a clinically used cardioprotective drug, which mechanism of action is based on the regulation of energy metabolism pathways through L-carnitine lowering effect. L-Carnitine biosynthesis enzyme γ-butyrobetaine hydroxylase and carnitine/organic cation transporter type 2 (OCTN2) are the main known drug targets of meldonium, and through inhibition of these activities meldonium induces adaptive changes in the cellular energy homeostasis. Since L-carnitine is involved in the metabolism of fatty acids, the decline in its levels stimulates glucose metabolism and decreases concentrations of L-carnitine related metabolites, such as long-chain acylcarnitines and trimethylamine-N-oxide. In a joint application meldonium enhances the action of antianginal drugs, Some antihypertensive drugs, cardiac glycosides.

Mildronate is the leading agent of the cardiovascular group,antiischemic agent of a metabolic action: Works as antiischemic cell protector in patients with angina pectoris, chronic heart failure, brain circulation disorders. Improves physical capacity and mental function in the case of ischemia and in healhty people.

The active substance of the drug is meldonium. The action of the drug is to prevent accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ischemic tissues and to block this highly oxygen-consuming process. Mildronate has a beneficial effect on cerebral circulation disorders and central nervous system functions. Mildronate is prescribed for patients with decreased working efficiency. Due to its unique mechanism of action Mildronate, depending on the prescribed dose, is widely used for the treatment of different heart and vascular diseases, as well as for the improvement of work capacity of healthy people at physical and mental overloads and during rehabilitation period.

Improves Mental Processes: Memory, Learning, Focus, Concentration, Processing of Information.

Reduces Fatigue, Increases Motivation and Alertness.

Protects Cells from Intoxication.

Improves Energy Levels and Faster Physical Recovery.

Improves Athletic Training and Competitive Performance.

Improves Microcirculation and Oxygen Delivery.

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Meldonium Indications for use.
For intake or in the introduction: in the complex treatment of coronary artery disease (angina, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy; in the complex therapy of acute and chronic disorders of cerebral circulation (strokes and cerebrovascular insufficiency); reduced working capacity, physical strain (incl. athletes), postoperative period to accelerate the rehabilitation; abstinence syndrome in chronic alcoholism (in combination with a specific treatment of alcoholism).
For parabulbarnom: acute circulatory disorder in the retina, hemophthalmos and retinal hemorrhages of different etiologies, thrombosis of the central retinal vein and its branches, retinopathy of different etiology (incl. Diabetic and hypertensive) - only parabulbarnom.

Meldonium pharmacological action

Meldonium improve metabolism, analog of gamma-butyrobetaine. Inhibits the synthesis of carnitine and transport of long-chain fatty acids through cell membranes, prevents accumulation in cells activated forms of oxygenated fatty acids.

The ischemia restores equilibrium processes oxygen delivery and consumption in cells, to prevent violations of transport ATP; simultaneously activates glycolysis, which proceeds without additional consumption of oxygen. As a result of reducing the concentration of carnitine is synthesized hard gamma-butyrobetaine, vasodilating properties. The mechanism of action determines the diversity of its pharmacological effects: increase efficiency, reducing the symptoms of the mental and physical stress, activation of tissue and humoral immunity, cardioprotective effect.

In the case of acute ischemic myocardial damage slows the formation of necrotic zone, shortens the rehabilitation period. In heart failure, increases myocardial contractility, increases exercise tolerance, reduces the frequency of angina attacks. In acute and chronic ischemic cerebrovascular disorders improves blood circulation in the ischemic focus, It promotes redistribution of blood to the ischemic area. Effective with vascular and dystrophic pathology of the fundus. It has a tonic effect on the CNS, eliminates functional disorders of the nervous system in patients with chronic alcoholism during abstinence syndrome.

Meldonium Side Effects

Cardio-vascular system: rarely - tachycardia, changes in blood pressure.

CNS: rarely - psychomotor agitation.

From the digestive system: rarely - dyspeptic symptoms.

Allergic reactions: rarely - itching, redness, rash, edema.

Meldonium Dosage

As part of combined therapy: 500-1000 mg once a day (or divide the daily dose for 2 times a day). Period of therapy is 4-6 weeks. Chronic disorders of cerebral circulation: 500 mg once a day. Period of therapy is 4-6 weeks. Intellectual and physical stress: 250 mg four times a day. Period of therapy is 10-14 days. Sport: 500-1000 mg two times a day before training. Duration of treatment during preparatory period is 2-3 weeks, during the period of competition 10-14 days. Chronic alcoholism: 500 mg four times a day. Period of therapy is 7-10 days.

Meldonium Ingredients

Active ingredient: Mildronate, THP, MET-88, Mildronats, Quaterine.

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