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Over the past decade, clinical evidence has emerged indicating a beneficial effect of selective serotonin reuptake inhibitors, tramadol, penile anesthesia, for the treatment of men with Premature ejaculation. But Dapoxetine, marketed as Priligy, is the first compound developed specially for the treatment of Premature ejaculation, on demand before intercourse. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. Dapoxetine is quickly absorbed and eliminated rapidly from the body. Its fast acting property makes it suitable for the on demand treatment of Premature ejaculation.
Priligy General Information
Priligy (dapoxetine; brand names include: Poxet) belongs to a group of medicines called selective serotonin reuptake inhibitors.
Priligy (dapoxetine hydrochloride) is used to treat men with frequent premature ejaculation in some countries.
An erection is the result of changes in blood flow in the penis, regulated by the parasympathetic nerves. In the absence of an erection the arteries, arterioles and cavernous cell bodies are narrowed by reducing the smooth muscle of their walls under the action of the sympathetic nerves. Venous blood freely flows off through venules located between the cells of the cavernous bodies and the bodies surrounding dense tunica. Erection begins when under the influence of parasympathetic nerves relax the smooth muscle cells of the cavernous bodies; as a result, these cells expand, the resistance therein and amplified falls inflow of arterial blood through the branches of the internal pudendal artery. This venules squeezed between the enlarged cells cavernous bodies and the inner surface of the tunica albuginea, and the outflow of venous blood is blocked.
Increasing the pressure in the cavernous bodies and increases the densification of the penis. In severe cases, when an artery as a result of any disease blocks blood flow, the only solution is to replace the diseased portion of the blood vessel as part of another vessel withdrawn from the patient's body to another, equally important, its location or removed from a suitable donor. Now, however, as a replacement can act as part of the artificial blood vessel, made with the help of three-dimensional printing technology from a special polymer material, developed by scientists.
Priligy Benefits
There is no effect from any drugs without potential side effects, but both should be balanced against each other. A benefit of dapoxetine in premature ejaculation certainly is meaningful, even if the time gain is not immense. The available dosages are 30mg and 60mg at 3, 6, 9 or 12 tablets per pack. Priligy should not be taken daily due to this mode of action. Because a permanently increased serotonin level reduces the number of receptors to which the messenger substance docks. The body notices that there is always too much serotonin and therefore replaces the sites where it is effective. Taking Priligy Dapoxetine on a daily basis, on the one hand, would mean that the dose must be steadily increased because the receptors are steadily decaying, and secondly, one would be in a bad mood after the drug is subsequently discontinued until new receptors are formed.
The drug is a prescription, but can be legally ordered online with an online recipe. Priligy works fast and is also broken down relatively quickly by your body, so you will not suffer from the excessive side effects that most anti-depressants are notorious for, such as a decrease in libido. Also, the use of Priligy has a positive effect on the sexual relationship between you and your partner due to the increased time to ejaculation.
How to take Priligy
The recommended dose is a single tablet (30mg), taken when you need it about 1 to 3 hours before sexual activity. Do not exceed taking a single tablet in 24 hours. Swallow the tablets whole with at least one full glass of water. Priligy may be taken with or without food. Avoid alcohol when taking Priligy. Take the tablet when you need it about 1 to 3 hours before sexual activity. Do not take more than one tablet once every 24 hours due to increased risk of side effects and lack of additional benefit.
Priligy Recommendations
Follow the directions for taking this medicine provided by your doctor. Take Priligy exactly as directed.
The usual dose is 30 mg. Your doctor may increase the dose to 60 mg.
Priligy should be taken 1 to 3 hours before sex.
You can take Priligy with or without food, but alcohol is not permitted.
Priligy Precautions
Tell your doctor before taking Priligy, if:
you have any serious medical conditions, especially heart problems;
you are currently taking any medicines for depression, schizophrenia, bipolar disorder, migraines, pain, or sleep problems.
Priligy is not suitable for teenagers, or for anyone with a history of significant heart disease, fainting or psychiatric illness. You take a tablet a couple of hours before you expect to have sex. You must not take Priligy more than once a day. Swallow the tablet whole with a full glass of water. The most common side effects are feeling dizzy or sick and headaches. If you feel dizzy, lightheaded, sick, sweaty, or like you might faint, sit with your head between your legs or lie down until the feeling passes.
Priligy Ingredients
Active ingredient: dapoxetine.